When is it time to let go?

People all start something with a dream, a dream of success.
Be this a new job or career, a relationship or marriage, a new venture or chance at a different life.

The uphill battles that accompany anything new sometimes feel impossible. Dealing with people, laws, criticisms and possibly failure must be one of the hardest things to overcome.
To make sure that you get out of bed every day and continue with that fight to get to your dream is definitely the hardest part of any venture.
Starting a new job, career or company is so daunting. Having done this myself, I can relate to the late night working just to get through the workload. The sleepless nights wondering where the next pay check is coming from.
Apart from all the elements you may or may not understand, like in my case business law and taxes.

I do feel particularly sorry for artists in this world.
This covers all artists like designers, writers, musicians and the like. Having to produce parts of yourself everyday for external scrutiny must be mortifying. I have seen clients ripping apart advertising concepts with no real knowledge of what they particularly wanted or no regard for their bad briefing techniques.
Don’t get me started on muso’s. These poor guys literally spend hours composing tracks and songs to put out on radio only to be dissed by the music fraternity that should be supporting them in the first place. It is the one industry that makes it so hard to succeed that natural talent goes to waste as people quit before they can make it.

My latest whinge is definitely about the state of relationships in the world.
I am the most disappointed with the lack of integrity and willingness to work on something that needs time and a bit of effort. This disposable nation we live in where there is instant gratification and throwaway anything and everything. Nothing is built to last and no one is prepared to put in the time and effort to work on something good.
I have found that with time and age, I have managed to work through the friendships that matter and are worth spending time and effort with and know when to let go and not pay attention and allocate time to the people that are not worth it.
The biggest question with regards to all of this is, when do you know when to let go?
When do you say no to toxic relationships, bad jobs and backstabbing work colleagues.
When do you take what the general public say seriously and when do you believe in yourself and your values that what they say does not matter?